SCAPE patients may be euvolemic or hypovolemic.The central, defining pathophysiological feature of SCAPE is pathologically elevated afterload due to systemic vasoconstriction and hypertension.With aggressive therapy, it may resolve very rapidly as well. Since SCAPE is a vicious spiral, this may develop very rapidly (hence the terminology “flash pulmonary edema”). SCAPE occurs due to a vicious spiral involving increasing sympathetic outflow, excessive afterload, and progressively worsening heart failure.Physiology of sympathetic crashing acute pulmonary edema (SCAPE) (#2) Enalaprilat, 1.25 mg IV (may repeat q15 minutes to a maximal dose of 5 mg).(#1) Clevidipine gtt (preferably) or nicardipine gtt.
#Pulmonary edema treatment plus
CPAP/BiPAP plus nitroglycerine infusion are usually adequate.Rapid reduction in Bp is essential (e.g., SBP Rx #3: if refractory hypertension ( more) (4) After SCAPE episode breaks, aggressively wean down nitroglycerine to avoid hypotension.(3) Aggressively uptitrate to 800 mcg/min if needed, targeting Bp reduction (SBP